Laboratory for Homeodynamics
Sa Kan YooMD, Ph.D.
- Location：Kobe / Developmental Biology Buildings
- E-mail：sakan.yoo[at]riken.jpPlease replace [at] with @.
- Lab Website
We study how organisms respond to disruption of homeostasis
Living organisms can cope with disruption of homeostasis such as injury and disease to a certain degree. This results in restoration of steady state homeostasis, death of affected tissues or ultimate organismal death. The outcome depends on the type of insults, species of animals and maturation of tissues. While the process is well recognized, we still do not know the mechanisms defining responses to disruption of homeostasis in different organs and species. Our research focuses on four fundamental questions targeting major disruption of homeostasis in organisms: 1) How do animals repair tissues upon injury? 2) How does oncogenic stress by cancer affect animals? 3) What is the mechanism of aging? 4) How do animals cope with abnormal nutrition? To do this, we utilize unrivaled genetics of the fruit fly, Drosophila melanogaster.
- How do animals repair tissues upon injury?
- How does oncogenic stress by cancer affect animals?
- What is the mechanism of aging?
- How do animals cope with abnormal nutrition?
Main Publications List
- Nishida H, Okada M, Yang L, et al.
Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila.
eLife 10. e59809 (2021) doi: 10.7554/eLife.59809
Sasaki A, Nishimura T, Takano T, et al.
white regulates proliferative homeostasis of intestinal stem cells during aging in Drosophila
Nature Metabolism doi: 10.1038/s42255-021-00375-x
Yoo SK, Pascoe H, Pereira T, et al.
Plexins function in epithelial repair in both Drosophila and zebrafish.
Nature Communications 7. 12282 (2016) doi:10.1038/ncomms12282
Yoo SK, Freisinger C, LeBert D, Huttenlocher A.
Early redox, Src family kinase and calcium signaling integrate wound responses and tissue regeneration in zebrafish.
Journal of Cell Biology 199. 225-34 (2012) doi: 10.1083/jcb.201203154
Yoo SK, Lam PY, Eichelberg M, et al.
Role of microtubules in neutrophil polarity and migration in live zebrafish.
Journal of Cell Science 125. 5702-10 (2012) doi: 10.1242/jcs.108324
Yoo SK, Starnes TW, Deng Q, Huttenlocher A.
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo .
Nature 480. 109-12 (2012) doi:10.1038/nature10632
Deng Q, Yoo SK, Cavnar P, et al.
Dual roles for Rac2 in neutrophil motility and retention in zebrafish hematopoietic tissues.
Developmental Cell 21. 735-45 (2011) doi: 10.1016/j.devcel.2011.07.013
Yoo SK, Huttenlocher A.
Spatiotemporal photolabeling of neutrophils during induction and resolution of inflammation in zebrafish.
Journal of Leukocyte Biology 89. 661-667 (2011) doi: 10.1189/jlb.1010567
Walters KB, Green JM, Surfus JC, et al.
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.
Blood 116. 2803-2811 (2010) doi: 10.1182/blood-2010-03-276972
Yoo SK, Deng Q, Cavnar P, et al.
Differential regulation of protrusion and polarity by PI(3)K during neutrophil motility in live zebrafish.
Developmental Cell 18. 226-236 (2010) doi: 10.1016/j.devcel.2009.11.015
Yoo SK, Huttenlocher A.
Innate immunity: wounds burst H2 O2 signals to leukocytes.
Current Biology 19. 553-5 (2009) doi: 10.1016/j.cub.2009.06.025
Nishita M, Yoo SK, Nomachi A, et al.
Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration.
Journal of Cell Biology 175. 555-62 (2006) doi: 10.1083/jcb.200607127