Laboratory for Next-Generation Imaging [Closed Mar. 2019] | RIKEN BDR

Laboratory for Next-Generation Imaging

Team Leader

Yasuyoshi WatanabeM.D., Ph.D.

    [Closed Mar. 2019]

We create innovative life science methodologies with our unprecedented imaging analysis technologies.

Research Summary

The Next-Generation Imaging Team aims to revolutionize the biological imaging analysis method by developing the application of the technologies invented and developed by ourselves. We developed the imaging apparatus GREI and MI-PET that are able to take three-dimensional images of multiple radio-tracers at a time distinguishing each kind of radionuclide, and that enable us to make non-invasive imaging analysis of multiple biological processes taking place in living organisms associated with health status and diseases. We have constructed the prototypes of the GREI and MI-PET for small animal imaging and succeeded in the world’s first demonstration of the technologies. Our ultimate goal is to realize clinical GREI and MI-PET systems. We are conducting applied researches on various models in collaboration with researchers and scientists in different fields to show the usefulness of these new imaging technologies clearly. In addition to establishing unprecedented imaging technologies to realize innovative medical imaging diagnostic method, we envisage pioneering new field of scientific researches in radiation therapeutics, radiation protection, bio-trace elements science and so forth.

Germanium semiconductor Compton camera GREI

Multiple PET probe simultaneous imaging system MI-PET

Research Theme

  • Development of the multiple radio-tracer imaging apparatus and its application
  • R&D of the multiple-molecular imaging technology
  • Fusion of molecular imaging science and metallomics research

Main Publications List

  • Fukuchi T, Okauchi T, Shigeta M, et al.
    Positron emission tomography with additional γ-ray detectors for multiple-tracer imaging
    Medical Physics 44. 2257-2266 (2017) doi: 10.1002/mp.12149
  • Munekane M, Ueda M, Motomura S, et al.
    Investigation of Biodistribution and Speciation Changes of Orally Administered Dual Radiolabeled Complex, Bis(5-chloro-7-[131I]iodo-8-quinolinolato)[65Zn]zinc
    Biological and Pharmaceutical Bulletin 40. 510–515 (2017) doi: 10.1248/bpb.b16-00945
  • Munekane M, Motomura S, Kamino S, et al.
    Visualization of biodistribution of Zn complex with antidiabetic activity using semiconductor Compton camera GREI.
    Biochemistry and Biophysics Reports 5. 211-215 (2015) doi: 10.1016/j.bbrep.2015.12.004
  • Tanioka M, Kamino S, Muranaka A, et al.
    Reversible Near-Infrared/Blue Mechanofluorochromism of Aminobenzopyranoxanthene
    Journal of American Chemical Society 137(20). 6436–6439 (2015) doi: 10.1021/jacs.5b00877
  • Higashikawa K, Yagi K, Watanabe K, et al.
    64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissues.
    PLOS ONE 9(11). e109866 (2014) doi: 10.1371/journal.pone.0109866
  • Kamino, S., Murakami, M., Tanioka, M, et al.
    Design and Syntheses of Highly Emissive Aminobenzopyrano-xanthene Dyes in the Visible and Far-Red Regions.
    Organic Letters 16(1). 258-261 (2014) doi: 10.1021/ol403262x
  • Shirasaki Y, Kamino S, Tanioka M, et al.
    New aminobenzopyranoxanthene-based colorimetric sensor for copper(II) ions with dual-color signal detection system.
    Chemistry – An Asian Journal 8(11). 2609-2613 (2013) doi: 10.1002/asia.201300515
  • Motomura S, Kanayama Y, Hiromura M, et al.
    Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms.
    Journal of Analytical Atomic Spectrometry 28(6). 934-939 (2013) doi: 10.1039/c3ja30185k
  • Taniguchi M, Fukunaka A, Hagihara M, et al.
    Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells.
    PLOS ONE 8(3). e58022 (2013) doi: 10.1371/journal.pone.0058022
  • Kamino S, Muranaka A, Murakami M, et al.
    A red-emissive aminobenzopyrano-xanthene dye: elucidation of fluorescence emission mechanisms in solution and in the aggregate state.
    Physical Chemistry Chemical Physics 15(6). 2131-2140 (2013) doi: 10.1039/c2cp43503a