Laboratory for Pathophysiological and Health Science | RIKEN BDR

Laboratory for Pathophysiological and Health Science

Team Leader

Yasuyoshi WatanabeM.D., Ph.D.

Photo of principal investigator

  • Location:Kobe / MI R&D Center Building
  • E-mail:yywata[at]riken.jpPlease replace [at] with @.

―Utilizing Molecules― Translational study from animal to human

Research Summary

We provide core technologies to realize health sciences including very early diagnosis, pathophysiology, and preemptive medicine using imaging biomarkers closely related to disease state and pre-disease state (ahead sick), to innovate medical science with promotion of collaborations among all center members.

Research Theme

  • Molecular imaging study on newly developed biomarkers for evaluation of health and pre-disease state
  • Molecular imaging study on newly developed biomarkers for evaluation of disease state
  • Development of molecular imaging indices for products to avoid deterioration of health

Main Publications List

  • Hu D, Li D, Shigeta M, et al.
    Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
    Biochemical and Biophysical Research Communications 535. 1-5 (2021) doi: 10.1016/j.bbrc.2020.12.035
  • Fukuchi T, Yamamoto S, Kataoka J, et al.
    Beta-ray imaging system with γ-ray coincidence for multiple-tracer imaging
    Medical Physics (2019) doi: 10.1002/mp.13947
  • Eguchi A, Fukuda S, Kuratsune H, et al.
    Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome.
    Brain Behavior and Immunity (2019) doi: 10.1016/j.bbi.2019.11.015
  • Fujiki K, Kanayama Y, Yano S, et al.
    211At-labeled immunoconjugate via a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics.
    Chemical science 10(7). 1936-1944 (2019) doi: 10.1039/c8sc04747b
  • Sakai K, Passioura T, Sato H, et al.
    Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.
    Nature Chemical Biology 15. 598–606 (2019) doi: 10.1038/s41589-019-0285-7
  • Takahashi K, Hosoya T, Onoe K,
    Association between aromatase in human brains and personality traits.
    Scientific Reports (2018) doi: 10.1038/s41598-018-35065-4
  • Kusuhara H, Takashima T, Fujii H, et al.
    Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.
    Drug Metabolism and Pharmacokinetics 32(6). 293-300(2017) doi: 10.1016/j.dmpk.2017.09.003
  • Nozaki S, Ozaki N, Suzuki S, et al.
    Development of diagnostic techniques for early rheumatoid arthritis using positron emission tomography with [11C]PK11195 and [11C]ketoprofen tracers.
    Molecular Imaging and Biology 19(5). 746-753(2017) doi: 10.1007/s11307-016-1039-5
  • Mizuno K, Kawatani J, Tajima K, et al.
    Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome.
    NeuroImage: Clinical 12. 600-606(2016) doi: 10.1016/j.nicl.2016.09.016
  • Mizuno K, Tanaka M, Tanabe HC, et al.
    Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome.
    NeuroImage: Clinical 9. 355-368 (2015) doi: 10.1016/j.nicl.2015.09.001
  • Doi H, Mawatari A, Kanazawa M, et al.
    Synthesis of 11C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography.
    The Journal of Organic Chemistry 80(12). 6250-6258 (2015) doi: 10.1021/acs.joc.5b00685
  • Ishii A, Karasuyama T, Kikuchi T, et al.
    The neural mechanisms of re-experiencing mental fatigue sensation: a magnetoencephalography study.
    PLOS ONE 10(3). e0122455(2015) doi: 10.1371/journal.pone.0122455
  • Shingaki T, Hume WE, Takashima T, et al.
    Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse.
    Pharmaceutical Research 32(8). 2538-2547(2015) doi: 10.1007/s11095-015-1642-1
  • Cui YL, Toyoda H, Sako T, et al.
    A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.
    Neuroimage 108. 17-22 (2015) doi: 10.1016/j.neuroimage.2014.12.047
  • Nakatomi Y, Mizuno K, Ishii A, et al.
    Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.
    Journal of Nuclear Medicine 55(6). 945-950 (2014) doi: 10.2967/jnumed.113.131045
  • Takahashi K, Hosoya T, Onoe K, et al.
    [11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain.
    Journal of Nuclear Medicine 55(5). 852-857 (2014) doi: 10.1523/JNEUROSCI.0220-16.2016


Yasuyoshi WatanabeTeam Leader yywata[at]
Yasuhiro WadaDeputy Team Leader yasuwada[at]
Shinji MotomuraDeputy Team Leader motomura[at]
Kei MizunoSenior Scientist* keimizuno[at]
Kayo TakahashiSenior Scientist kayo.takahashi[at]
Yousuke KanayamaResearch Scientist ykana[at]
Akihiro SasakiResearch Scientist akihiro.sasaki[at]
Hiroshi MizumaResearch Scientist mizuma_hiroshi[at]
Takayoshi NakaokaResearch Scientist
Tomonori FukuchiResearch Scientist tfukuchi[at]
Kyosuke WatanabeResearch Scientist *
Emi YamanoResearch Scientist *
Kayo OnoeTechnical Scientist
Riyo ZochiTechnical Scientist
Miki GotoTechnical Scientist
Emi HayashinakaExpert Technician
Yuka NakataniTechnical Staff I yu-nakatani[at]
Shino OwadaTechnical Staff I
Satsuki IrieTechnical Staff I
Yoshino MatsumotoTechnical Staff I
Chie UedaTechnical Staff I
Kanako TajimaTechnical Staff I *
Akina HigashiResearch Part-time Worker II
Shuhei YamaguchiResearch Part-time Worker II
Yoshimi TakemotoAdministrative Part-time Worker II
Maya MitsunoAdministrative Part-time Worker II
Natsumi OtsukaTemporary Staffing
Kai ZhangVisiting Researcher
Eriko KawaiVisiting Researcher
Mai ShibataAssistant
Yoko NagatomoAssistant *
Miki FujiwaraAssistant *

*:concurrent / Please replace [at] with @.