Laboratory for Neuroepitranscriptomics | RIKEN BDR

Laboratory for Neuroepitranscriptomics

Team Leader

Dan Ohtan WangPh.D.

Photo of principal investigator

  • Location:Kobe / Developmental Biology Buildings
  • E-mail:ohtan[at]riken.jpPlease replace [at] with @.

Research Summary

The “brain” and “RNA” are the two keywords associated with our research. Using dynamic synapses and their association with intellectual ability, memory, and susceptibility to neurological disorders as the conceptual framework, we are studying the role of a novel RNA neuroepigenetic mechanism in the central nervous system in synapse function. The outcome of this quest will allow us to understand the regulatory mechanisms of gene networks for experience-based behavioral changes and diseases, over the course of our lifespan. Our research is supported by the current revolution in quantitative and omics technology, fluorescence imaging, and genetic animal model systems.

Research Theme

  • Neurosciences
  • Post-transcriptional regulation
  • RNA chemical modification

Main Publications List

  • Madugalle SU, Meyer K, Wang DO, Bredy TW.
    RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.
    Trends in Neurosciences 43, 1011-1023 (2020) doi: 10.1016/j.tins.2020.09.005
  • Wang DO.
    RNA modifications in the central nervous system.
    Oxford Handbook on Neuronal Protein synthesis doi: 10.1093/oxfordhb/9780190686307.013.23
  • Roy R, Shiina N, Wang DO.
    More dynamic, more quantitative, unexpectedly intricate: advanced understanding on synaptic RNA localization in learning and memory.
    Neurobiology of Learning and Memory 168, 107149 (2020)
  • Wang DO.
    Mapping m6A and m1A with mutational signatures.
    Nature Methods (2019) doi: 10.1038/s41592-019-0636-z
  • Kashida S, Wang DO, Saito H, Gueroui Z.
    Nanoparticle-based local translation reveals mRNA as translation-coupled scaffold with anchoring function.
    Proceedings of the National Academy of Sciences of the United States of America 116(27), 13346-13351 (2019)
  • Merkurjev D, Hong WT, Iida K, et al.
    Synaptic N6 methyladenosine (m6A) reveals functional partitioning of localized transcripts.
    Nature Neuroscience 21, 1004–1014 (2018)
  • Oomoto I, Hirano-Suzuki A, Umeshima H, et al.
    ECHO-liveFISH: in vivo RNA Labeling Reveals Dynamic Regulation of Nuclear RNA Foci in Living Tissues.
    Nucleic Acids Research (2015) doi: 10.1093/nar/gkv614
  • Meer E, Wang DO, Kim SM, et al.
    Identification of a cis-element that localizes mRNA to synapses.
    Proceedings of the National Academy of Sciences of the United States of America 109(12), 4639-44 (2012)
  • Wang DO, Martin KC, Zukin RS.
    Spatially restricting gene expression by local translation at synapses.
    Trends in Neurosciences 33(4), 173-82 (2010)
  • Wang DO, Kim SM, Zhao Y, et al.
    Synapse- and stimulus-specific local translation during long-term neuronal plasticity.
    Science 324(5934), 1536-40 (2009)