Laboratory for Nutritional Biology | RIKEN BDR

Laboratory for Nutritional Biology

Team Leader

Fumiaki ObataPh.D.

Photo of principal investigator

  • Location:Kobe / Developmental Biology Buildings
  • E-mail:fumiaki.obata[at]riken.jpPlease replace [at] with @.

Unveiling the "logic" behind the dietary regulation of healthspan

Research Summary

Our healthspan is influenced by the dietary environment. Diet contributes to metabolic and physiological homeostasis by altering nutritional balance and gut microbiota, yet the molecular mechanisms are not fully understood. Our laboratory studies the functions of each nutrient and gut bacterial species that are dynamically altered in response to various dietary conditions. We also aim to elucidate the mechanisms by which early-life diet impacts lifelong health. Our goal is to reveal evolutionarily conserved "dietological" mechanisms that govern organismal homeostasis and healthspan.

Research Theme

  • Physiological functions of nutrients and gut microbiota
  • Regulatory mechanism of healthspan by early-life environment
  • Regulation of healthspan by dietary amino acids and their metabolism
  • Molecular mechanisms of thermotolerance

Main Publications List

  • Yamauchi T, Oi A, Kosakamoto H, et al.
    Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
    iScience 23, 101477 (2020)
  • Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
    Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
    Cell Reports 32, 107938 (2020)
  • Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
    Nutritional control of stem cell division through S-adenosylmethionine in Drosophila intestine.
    Developmental Cell 44, 741-751 (2018)
  • Obata F, Fons CO, Gould AP.
    Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
    Nature Communications 9, 975 (2018)
  • Obata F, Miura M.
    Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
    Nature Communications 6, 8332 (2015)
  • Obata F, Tanaka S, Kashio S, et al.
    Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.
    BMC Biology 13, 48 (2015)
  • Obata F, Kuranaga E, Tomioka K, et al.
    Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
    Cell Reports 7, 821-833 (2014)