Laboratory for Multiscale Biosystem Dynamics | RIKEN BDR

Laboratory for Multiscale Biosystem Dynamics

Team Leader

Chikara FurusawaPh.D.

Photo of principal investigator

  • Location:Osaka / Quantitative Biology Buildings
  • E-mail:chikara.furusawaPlease replace [at] with @.
  • Lab Website

Universal Biology based on theoretical and experimental approaches

Research Summary

We study multi-scale dynamics in biological systems, such as differentiation and evolution, using both theoretical and experimental approaches. For example, we analyze phenotypic/genetic changes of microorganisms during experimental evolution, to unveil interplay between the dynamics of adaptation and evolution. We also study the dynamics differentiation process of stem cells using theoretical models to understand how cell-cell interactions bring about cellular diversifications and robust development of multicellular systems.

Research Theme

  • Analysis of developmental process using theoretical cell models
  • Study of evolutionary dynamics of microorganisms by comprehensive phenotypic/genetic analysis
  • Development of algorithm for high-resolution comprehensive phenotypic/genetic analysis

Main Publications List

  • Maeda T, Iwasawa J, Kotani H, et al.
    High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli.
    Nature Communications 11. 5970 (2020) doi: 10.1038/s41467-020-19713-w
  • Furusawa C, Horinouchi T, Maeda T.
    Toward prediction and control of antibiotic-resistance evolution.
    Current Opinion in Biotechnology 54. 45-49 (2018) doi: 10.1016/j.copbio.2018.01.026
  • Yoshida M, Reyes SG, Tsuda S, et al.
    Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro.
    Nature Communications 8. 15589 (2017) doi: 10.1038/ncomms15589
  • Horinouchi T, Suzuki S, Hirasawa T, et al.
    Phenotypic convergence in bacterial adaptive evolution to ethanol stress.
    Bmc Evolutionary Biology 15. 180 (2015) doi: 10.1186/s12862-015-0454-6
  • Furusawa C, Kaneko K.
    Global relationships in fluctuation and response in adaptive evolution.
    Journal of the Royal Society Interface 12(109). 20150482 (2015) doi: 10.1098/rsif.2015.0482
  • Kaneko K, Furusawa C, Yomo T.
    Universal Relationship in Gene-Expression Changes for Cells in Steady-Growth State.
    Physical Review X 5(1). 011014 (2015) doi: 10.1103/PhysRevX.5.011014
  • Suzuki S, Horinouchi T, Furusawa C.
    Prediction of antibiotic resistance by gene expression profiles.
    Nature Communications 5. 5792 (2014) doi: 10.1038/ncomms6792
  • Horinouchi T, Minamoto T, Suzuki S, et al.
    Development of an Automated Culture System for Laboratory Evolution.
    Jala 19(5). 478-482 (2014) doi: 10.1177/2211068214521417
  • Ohno S, Shimizu H, Furusawa C.
    FastPros: screening of reaction knockout strategies for metabolic engineering.
    Bioinformatics 30(7). 981-987 (2014) doi: 10.1093/bioinformatics/btt672
  • Furusawa C, Kaneko K.
    A Dynamical-Systems View of Stem Cell Biology.
    Science 338(6104). 215-217 (2012) doi: 10.1126/science.1224311
  • Furusawa C, Kaneko K.
    Adaptation to Optimal Cell Growth through Self-Organized Criticality.
    Physical Review Letters 108(20). 208103 (2012) doi: 10.1103/PhysRevLett.108.208103

All Publications