Laboratory for Biofunction Dynamics Imaging | RIKEN BDR

Laboratory for Biofunction Dynamics Imaging

Team Leader

Yi-Long CuiPh.D.

Photo of principal investigator

  • Location:Kobe / MI R&D Center Building
  • E-mail:cuiyl[at]riken.jpPlease replace [at] with @.

Unlocking dynamics of functional molecules in vivo

Research Summary

Over millions of years of evolution, living organisms have developed an optimum internal environment, and functional molecules involved in complex hierarchical systems precisely interact with the surrounding microenvironment to ensure an optimum state is maintained. Deviations from the optimum state are known to suppress the functional performance and/or induce disease due to the disruption of the spatial-temporal dynamics of functional molecules in these complex systems. For the purpose of comprehensively exploring the molecular dynamics in complex systems, we are trying to establish an integrated research system combining positron emission tomography and classic research techniques, including electrophysiology, behavioral pharmacology, histology and genetic engineering approaches, and to thereby carry out comprehensive investigations covering the entire hierarchy of molecules, cells, organs and systems. We are particularly interested in unlocking the mysteries of the brain, especially regarding such factors as placebo analgesia and fatigue sensation.

Research Theme

  • Development of a PET imaging based integrated research system to elucidate the molecular/cellular mechanisms of the psychiatric processes
  • Establishment of PET imaging-based evaluation platform for pharmacokinetics
  • Development of cancer-specific PET imaging methods and evaluation of novel diagnostic & therapeutic drug efficacy

Main Publications List

  • Hu D, Li D, Shigeta M, et al.
    Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
    Biochemical and Biophysical Research Communications 535. 1-5 (2021) doi: 10.1016/j.bbrc.2020.12.035
  • Zeng Y, Hu D, Yang W, Hayashinaka E, et al.
    A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
    NeuroImage (2018) doi: 10.1016/j.neuroimage.2018.06.009
  • Kanzaki A, Okauchi T, Hu D, et al.
    Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model.
    Journal of Neuroscience Research 94(5). 424-429 (2016) doi: 10.1002/jnr.23718
  • Cui YL, Toyoda H, Sako T, et al.
    A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.
    NeuroImage 108. 17-22 (2015) doi: 10.1016/j.neuroimage.2014.12.047
  • Fujita S, Mizoguchi N, Aoki R, et al.
    Cytoarchitecture-dependent decrease in propagation velocity of cortical spreading depression in the rat insular cortex revealed by optical imaging.
    Cerebral Cortex 26(4). 1580-1589 (2016) doi: 10.1093/cercor/bhu336
  • Mukai H, Ozaki D, Cui Y, et al.
    Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides.
    Journal of Controlled Release 180. 92-99 (2014) doi: 10.1016/j.jconrel.2014.02.014
  • Sako T, Hasegawa K, Nishimura M, et al.
    Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-68-DOTA-octreotide: A potential PET tracer for beta cell mass measurement.
    Biochemical and Biophysical Research Communications 442(1-2). 79-84 (2013) doi: 10.1016/j.bbrc.2013.11.001
  • Shingaki T, Takashima T, Ijuin R, et al.
    Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [C-11]Dehydropravastatin in Rats.
    Journal of Pharmacology and Experimental Therapeutics 347(1). 193-202 (2013) doi: 10.1124/jpet.113.206425
  • Takashima T, Nagata H, Nakae T, et al.
    Positron emission tomography studies using (15R)-16-m-[11 C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport..
    Journal of Pharmacology and Experimental Therapeutics 335(2). 314-323 (2010) doi: 10.1124/jpet.110.170092
  • Akazawa KH, Cui YL, Tanaka M, et al.
    Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry.
    Neuroscience Research 66(4). 372-379 (2010) doi: 10.1016/j.neures.2009.12.009
  • Cui YL, Takashima T, Takashima-Hirano M, et al.
    11 C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression.
    Journal of Nuclear Medicine 50(11). 1904-1911 (2009) doi: 10.2967/jnumed.109.066498
  • Cui YL, Takamatsu H, Kakiuchi T, et al.
    Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study.
    Stroke 37(11). 2830-2836 (2006) doi: 10.1161/01.STR.0000245088.60282.22


Yi-Long CuiTeam Leader cuiyl[at]
Tsuyoshi TaharaResearch Scientist tsuyoshi.tahara[at]
Di HuResearch Scientist[at]
Takashi OkauchiResearch Associate
Yuping WuResearch Associate
Ying ZengResearch Associate
Michiko InoueTechnical Staff I
Mika ShigetaTechnical Staff I
Danxi LiInternational Program Associate
Tianliang HuangJunior Research Associate
Kazuto KobayashiVisiting Scientist
Masayuki KobayashiVisiting Scientist
Tetsuya SasabeVisiting Scientist
Susumu SetogawaVisiting Scientist
Koki HasegawaVisiting Scientist
Yoshio IguchiVisiting Scientist
Naoko UedaAssistant naoko.ueda[at]

*:concurrent / Please replace [at] with @.