Laboratory for Biofunction Dynamics Imaging
- Location：Kobe / MI R&D Center Building
- E-mail：cuiyl[at]riken.jpPlease replace [at] with @.
Unlocking dynamics of functional molecules in vivo
Over millions of years of evolution, living organisms have developed an optimum internal environment, and functional molecules involved in complex hierarchical systems precisely interact with the surrounding microenvironment to ensure an optimum state is maintained. Deviations from the optimum state are known to suppress the functional performance and/or induce disease due to the disruption of the spatial-temporal dynamics of functional molecules in these complex systems. For the purpose of comprehensively exploring the molecular dynamics in complex systems, we are trying to establish an integrated research system combining positron emission tomography and classic research techniques, including electrophysiology, behavioral pharmacology, histology and genetic engineering approaches, and to thereby carry out comprehensive investigations covering the entire hierarchy of molecules, cells, organs and systems. We are particularly interested in unlocking the mysteries of the brain, especially regarding such factors as placebo analgesia and fatigue sensation.
- Development of a PET imaging based integrated research system to elucidate the molecular/cellular mechanisms of the psychiatric processes
- Establishment of PET imaging-based evaluation platform for pharmacokinetics
- Development of cancer-specific PET imaging methods and evaluation of novel diagnostic & therapeutic drug efficacy
Main Publications List
Hu D, Li D, Shigeta M, et al.
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
Biochemical and Biophysical Research Communications 535. 1-5 (2021) doi: 10.1016/j.bbrc.2020.12.035
Zeng Y, Hu D, Yang W, Hayashinaka E, et al.
A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
NeuroImage (2018) doi: 10.1016/j.neuroimage.2018.06.009
Kanzaki A, Okauchi T, Hu D, et al.
Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model.
Journal of Neuroscience Research 94(5). 424-429 (2016) doi: 10.1002/jnr.23718
Cui YL, Toyoda H, Sako T, et al.
A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.
NeuroImage 108. 17-22 (2015) doi: 10.1016/j.neuroimage.2014.12.047
Fujita S, Mizoguchi N, Aoki R, et al.
Cytoarchitecture-dependent decrease in propagation velocity of cortical spreading depression in the rat insular cortex revealed by optical imaging.
Cerebral Cortex 26(4). 1580-1589 (2016) doi: 10.1093/cercor/bhu336
Mukai H, Ozaki D, Cui Y, et al.
Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides.
Journal of Controlled Release 180. 92-99 (2014) doi: 10.1016/j.jconrel.2014.02.014
Sako T, Hasegawa K, Nishimura M, et al.
Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-68-DOTA-octreotide: A potential PET tracer for beta cell mass measurement.
Biochemical and Biophysical Research Communications 442(1-2). 79-84 (2013) doi: 10.1016/j.bbrc.2013.11.001
Shingaki T, Takashima T, Ijuin R, et al.
Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [C-11]Dehydropravastatin in Rats.
Journal of Pharmacology and Experimental Therapeutics 347(1). 193-202 (2013) doi: 10.1124/jpet.113.206425
Takashima T, Nagata H, Nakae T, et al.
Positron emission tomography studies using (15R)-16-m-[11 C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport..
Journal of Pharmacology and Experimental Therapeutics 335(2). 314-323 (2010) doi: 10.1124/jpet.110.170092
Akazawa KH, Cui YL, Tanaka M, et al.
Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry.
Neuroscience Research 66(4). 372-379 (2010) doi: 10.1016/j.neures.2009.12.009
Cui YL, Takashima T, Takashima-Hirano M, et al.
11 C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression.
Journal of Nuclear Medicine 50(11). 1904-1911 (2009) doi: 10.2967/jnumed.109.066498
Cui YL, Takamatsu H, Kakiuchi T, et al.
Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study.
Stroke 37(11). 2830-2836 (2006) doi: 10.1161/01.STR.0000245088.60282.22
|Yi-Long CuiTeam Leader||cuiyl[at]riken.jp|
|Tsuyoshi TaharaResearch Scientist||tsuyoshi.tahara[at]riken.jp|
|Di HuResearch Scientist||di.hu[at]riken.jp|
|Takashi OkauchiResearch Associate|
|Yuping WuResearch Associate|
|Ying ZengResearch Associate|
|Michiko InoueTechnical Staff I|
|Mika ShigetaTechnical Staff I|
|Danxi LiInternational Program Associate|
|Tianliang HuangJunior Research Associate|
|Kazuto KobayashiVisiting Scientist|
|Masayuki KobayashiVisiting Scientist|
|Tetsuya SasabeVisiting Scientist|
|Susumu SetogawaVisiting Scientist|
|Koki HasegawaVisiting Scientist|
|Yoshio IguchiVisiting Scientist|
*：concurrent / Please replace [at] with @.